Home
Contact info'
Bibliography
PhD projects
Personnel
Research Details
Data
Models
Software
Funding
Collaborators
Old News archive

24h rhythm of luminescence

The Millar research group
www.amillar.org SynthSys Seminars; Andrew's pages on Edinburgh Research Explorer

horizontal rule

News (old news is here)

bullet

Laura et al. showed flexible timing across species (New Phytol. 2014) + data in BioDare, 10 models in PlaSMo.

bullet

Tomasz and Anne compared 6 period analysis methods (PLosone 2014),
all now online on BioDare, with step by step protocols (Meth. Mol. Biol. 2014)

bullet

Daniel and Alexandra's clock-regulated starch degradation (JRS Interface 2013), with models in PlaSMo.

bullet

ROBuST project identifies HOS1 as a clock gene (Plant Cell)

bullet

ROBuST models rhythmic CBF cold pathways (Plant Journal).

bullet

CK1 is a clock-affecting kinase in the green lineage, PLoSone and BMC Cell Bio 2013

bullet

ROBuST temperature-compensated clock model predicts LHY regulation, Mol Syst Biol 2013.

horizontal rule

Biological Clocks

Plants, fungi, animals, some bacteria and archaea have internal, 24-hour clocks. These "circadian" clocks affect our lives in many ways, through industry, agriculture and human health.

Web tutorials on biological clocks: try these old pages first, if circadian clocks are new to you.

Our Research

Our research aims to understand how the circadian clock is constructed and adjusted, how it affects plant life and why the clock mechanisms are so complex. Among the cogs of the biological clockwork are a small set of genes that rhythmically regulate each other's activity. We study these "clock genes" in Arabidopsis, which is a small plant with a big following, and the marine alga Ostreococcus, which is one of the smallest eukaryotic cells. Molecular genetics and transgenic plants/algae help us by revealing rhythms that are usually invisible: we use a reporter gene called luciferase to send us video footage when other genes are active, like the 24-hour loop at the top of this page. We are also studying how biological rhythms benefit the organism by controlling metabolism, growth and seasonal flowering times, using quantitative timeseries experiments and mathematical modelling.

The circadian clock is an excellent system to develop new methods in Systems Biology, as we do with many collaborators in SynthSysMathematical modelling helps us to understand the complex data and to identify the principles behind the molecular detail. We were using the simpler clock of Ostreococcus to test those principles, when we also discovered a different, non-transcriptional clock mechanism that does not require rhythmic gene activity. We are now using proteomics and chemical biology to identify the cogs and gears of this ancient clock.

PhD studentship projects.

horizontal rule

Andrew Millar holds a Chair of Systems Biology in SynthSys at the University of Edinburgh. He was previously involved in the Scottish Universities Life Sciences Alliance (SULSA), in GARNet, the UK's Arabidopsis research network, and was founding Director of SynthSys' predecessor, the Centre for Systems Biology at Edinburgh (CSBE).  Here's a short biography with links to other resources.

horizontal rule

Privacy and cookies. All content copyright University of Edinburgh unless otherwise stated.