Welcome to the Circadian
Modelling homepage. This site is aimed at providing
support, news and updates for those using our Circadian Modelling software.
Click here, or go to
Note that some versions of Windows give several apparent error
messages during installation - these are not critical, see
Models. If you have Circadian Modelling
and want new models, click here.
Paul Brown (p.e.brown[at]warwick.ac.uk)
if you have problems downloading.
What is Circadian
Screenshots are available in our on-line
Mathematical modelling provides an invaluable
tool for understanding complex systems such as the circadian
clock. There are now published models for a number of different
organisms. However, despite this enormous potential, the
usefulness of modelling to the wider biological community is
under exploited due to apparent inaccessibility to
non-mathematicians, in particular the difficulties involved for
a researcher in modifying someone else's published simulations
to suit their own particular research interest. We have
attempted to rectify this problem and bridge the gap between
theoretical and experimental biology by developing Circadian
Modelling, a flexible, user-friendly software interface
for running simulations. It is aimed primarily at experimental
biologists who wish to use modelling to rapidly simulate their
own chosen phenotypes and experimental protocols.
The models themselves are separate from the user
interface. Once Circadian Modelling is installed, a range of
published models can be downloaded from our website. These are
then presented to the user in a biologically relevant way. The
user can easily specify the necessary biological parameters,
controlling both phenotype and the experimental protocol. Modules allow the automated simulation of common
circadian experimental protocols, such as PRCs, with just a few
clicks of the mouse. Results are presented in the form of a
Microsoft Excel workbook, thus the full power of Excel is
available to further analyse the data.
Our principle aim is that users will be able easily ‘fine-tune’ simulations to
suit their particular experimental interests. Published models can be altered in
any way the user wishes, and subject to any experimental protocol that is
required. In addition, we hope that the capability of our software to visualise
changing levels of gene expression will prove useful in the teaching of
We welcome any feedback. Please use the form
below to send us your comments, suggestions, or any questions about Circadian Modelling
Other Software Tools
Our Colleagues Boris Shulgin and David Rand in
a set of analytical tools for Matlab users
allowing powerful mathematical analysis of clock models.
Software on this site is provided free of charge for
academic research without guarantees or support either explicit or implied.